We investigate the effect of the soft gravitons on the microscopic matter dynamics in de Sitter space. Scale invariance of the soft graviton propagator is the source of the de Sitter symmetry breaking. We find quartic, Yukawa and gauge couplings become time dependent and diminish with time. In a simple model, the cosmological constant is self-tuned to vanish due to UV-IR mixing effect. We also discuss phenomenological implications such as SUSY breaking.