Even though the LHC searches so far did not unveil the new physics (NP)particles, the B-physics experiments at LHCb, BaBar and Belle hint towards deviations from Lepton Flavor Universality in semi-leptonic decays. In this talk I will review the status of these puzzles, and discuss the possibilities for BSM scenarios. Particular emphasis will be given to the implications for Lepton Flavor Violation in B meson decays