Our group promotes research in the field of life science using synchrotron radiation, for which we have developed state-of-the-art beamlines and experimental devices. We have expanded our research to link biopolymers to cells and tissues using X-ray crystal structural analysis, small-angle X-ray scattering, X-ray imaging, and X-ray cell irradiation.
In addition to the research by the program staff, our school promotes interuniversity research as one of the interuniversity research institutes. We also conduct research in cooperation with industry, academia, and the government in the fields of pharmacy, nutrition, and the environment, to name a few.
We are studying the intranuclear reactions in a cell, such as transcription and replication from a chromatin template, using the spatial structures of biopolymers such as proteins, DNA, and RNA. In particular, with a focus on the relationship between epigenetic information and intranuclear reactions, we are studying how the functions of individual molecules integrate to yield complex functions.
We are studying the causes of infection and diseases by studying the spatial structures of molecules (molecular complex) related to infectious and other diseases, and we aim to establish the foundation for the discovery of drugs to fight these diseases.
We are studying the spatial structures of intermediate enzymes to elucidate the relationship between the spatial structures and the functions of enzymes that help chemical reactions in a living body.
We are studying the structure of biopolymers (biopolymer complex) to elucidate the mechanisms of intracellular and extracellular signaling and substance transportation.
We are studying the effects of radiation on cells, from the molecular level to the tissue level, by using the variable energy of synchrotron radiation and microbeams obtained from high-luminance light.
To obtain knowledge from imaging data about a living body and various diseases, we are developing an imaging system that utilizes the characteristics of synchrotron radiation, and conducting research into its application.
We are upgrading to new analysis methods and beamlines, and developing multifaceted analysis methods by combining multiple methods. We will provide these methods for joint usage.
|SENDA, Toshiya||Professor||Structural biology|
|IGARASHI, Noriyuki||Professor||Structural biology|
|SHIMIZU, Nobutaka||Professor||Structural biology|
|HYODO, Kazuyuki||Professor (KEK)||Medical imaging|
|KATO, Ryuichi||Assoc. Professor||Structural biology|
|KAWASAKI, Masato||Assoc. Professor||Structural biology|
|MATSUGAKI, Naohiro||Assoc. Professor||Structural biology|
|USAMI, Noriko||Assoc. Professor||Radiation biology|
|YAMADA, Yusuke||Assistant Professor||Structural biology|
|HIKITA, Masahide||Assistant Professor||Structural biology|
|TAKAGI, Hideaki||Assistant Professor||SAXS, Polymer Science|
BL-1A, BL-5A, BL-17A, NE-3A, NW-12A
BL-6A, BL-10C, BL-15A2
BL-14C, (NE-5A), NE-7A
Structural Biology Research Center https://www2.kek.jp/imss/sbrc/eng/