The most modern way to understand quark confinement involves the notion of `1-form symmetry’. The reason we care about quark confinement is of course because of its implications for real-world QCD, but unfortunately confinement is believed to be only an approximate concept in the real world, so it is not tied to any exact symmetries. However, confinement is supposed to become well-defined in the large N limit of QCD, and so one might expect large N QCD to have a Z_N 1-form symmetry. However, to our surprise, in recent work we found some severe obstructions to the conjecture that large N QCD has a Z_N 1-form symmetry. Our results suggest that a symmetry-based understanding of (approximate) confinement in QCD may require some further generalization of the notion of generalized global symmetries.