Nuclear Lattice Effective Field Theory (NLEFT) is a robust framework that integrates lattice techniques, effective field theory, and quantum Monte Carlo (QMC) algorithms to provide ab initio solutions to the nuclear many-body Schrödinger equation. This talk will introduce the fundamental principles of NLEFT and highlight recent advancements, including a novel solution to the Monte Carlo sign problem in nuclei, the renormalization group (RG) evolution of lattice-regulated nuclear EFT, and various applications for computing key nuclear observables. These developments demonstrate the framework’s efficiency and versatility in tackling complex challenges in nuclear many-body physics.