SBRC

KEK

Projects

Ongoing projects

Toshiya Senda

Ryuichi Kato

  • 2023.04 - 2028.03 Grant-in-Aid for Scientific Research (B) (Co-Investigator)
    Molecular basis and physiological significance of O-mannosyl glycans in mammals
  • 2022.10 - 2025.03 AMED Practical Research Project for Life-Style related Diseases including Cardiovascular Diseases and Diabetes Mellitus (Co-Investigator)
    Development of a comprehensive treatment system for diabetes and obesity-related diseases by targeting metabolite sensor molecules

Masato Kawasaki

  • 2021.04 – 2024.03 Grant-in-Aid for Scientific Research (C) (Principal Investigator)
    A novel method for preparing cryo-EM grids by using an amphipathic peptide
  • 2022.04 -2027.3 AMED Basis for Supporting Innovative Drug Discovery and Life Science Research (Co-Investigator)
    Support of production and structural analysis of disease-related membrane proteins

Toshio Moriya

  • 2023.04 -2026.03 Grant-in-Aid for Scientific Research (B) (Principal Investigator)
    Analyzing the continuous dynamics of protein structures through single-molecule structure analysis with cryogenic electron microscopy

Mikio Tanabe

  • 2024.04 - 2028.03 Grant-in-Aid for Scientific Research (B) (Principal Investigator)
    Deorphanization of MFS-type Multidrug Efflux Transporters: Dual Inhibition of Drug Efflux and Physiological Substrate Transport 
  • 2023.04 - 2025.03 2023.04 - 2025.03 NJRC Network Joint Research Center for Materials and Devices (Principle Investigator)
    Elucidation of the original physiological Functions of drug efflux transporters by AI-based structural and metabolic pathway analysis

Miki Senda

  • 2024.04 - 2027.03 Grant-in-Aid for Scientific Research (C) (Principal Investigator)
    Structural analysis to elucidate the activation mechanism of Calmodulin-Dependent Kinase and Its application to the treatment of heart failure

Genoveso Michelle Jane

  • 2023.08 - 2025.03 Grant-in-Aid for Research Activity Start-up (Principal Investigator)
    Molecular Mechanism of Histone Chaperone Activity Based on IDR Structural Plasticity of NPM1

Finished projects

  • 2017.04 - 2022.03 Basis for Supporting Innovative Drug Discovery and Life Science Research  (AMED BINDS Project) Structural Analysis Unit
    "Analysis and Users support by BINDS - accelating protein structural life science analysis and enhancement of the state-of-the-art techonology"
      (Principal Investigator: Toshiya Senda)
  • 2015.04 - 2018.03 Grant-in-Aid for Scientific Research on Innovative Areas, Challenging Exploratory Research
    Structural anlaysis of membrane protein complexes using S-SAD method
    (Principal Investigator: Ryuichi Kato)
  • 2015.04 - 2018.03 Grant-in-Aid for Scientific Research on Innovative Areas, Scientific Research (C)
    Investigation of membrane curveture formation by SYLF domain
    (Principal Investigator: Masato Kawasaki)
  • 2015.04 - 2017.03 Grants-in-Aids for Scientific research (KAKENHI), Grant-in-Aid for Scientific Research on Innovative Areas, Challenging Exploratory Research
    A new frontier of structural biology using ultra high speed micro pixeled detector
    (Co-Investigator: Nobutaka Shimizu)
  • 2015.04 - 2018.03 Grant-in-Aid for Scientific Research on Innovative Areas, Scientific Research (C)
      Invetigation of molecular mechanism of the regulation of transcription by Nuclear Receptor
      (Principal Investigator: Fumiaki Yumoto)
  • 2015.08 - 2017.03 Grant-in-Aid Research Activity Start-up
      Investigation of molecular mechanism of transphosphorylation by a phosphatidylinositol kinase
      (Principal Investigator: Tomomi Sato)
  • 2014.04 - 2016.03 Grant-in-Aid for Scientific Research on Innovative Areas, Challenging Exploratory Research (Principal Investigator)
      Establish a method of increasing the success rate of crystallization under Anaerobic conditions
      (Principal Investigator: Miki Senda)
  • 2014.04 - 2016.03 Grant-in-Aid for Young Scientists (B)
      Structural and functional relationship of glycosyl transferase causing Muscular Dystrophy
      (Principal Investigator: Naoyuki Kuwabara)
  • 2013.10 - 2018.03 Photon and Quantum Basic Research coordinated development program by MEXT
       Investigation of redox dependent affinity regulating mechanism of electron-transfer protein
      (Principal Investigator: Toshiya Senda)
  • 2013.08 - 2015.03 Grant-in-Aid Research Activity Start-up
       Analysis in molecular mechanism of transcriptional activation of LRH-1 by beta-catenin
      (Principal Investigator: Fumiaki Yumoto)
  • 2013.10 - 2017.03 Strategic Basic Research Programs PRESTO
      Analysis of the regulatory mechanisms of chromatin transcription through the strucural analysis of TFIID
      (Principal Investigator: Naruhiko Adachi)
  • 2012. - 2016. Platform for Drug Discovery, Informatics, and Structural Life Science (PDIS) (Analysis Core - Representative)
      Analysis and Users support by PDIS - accelating protein structural life science analysis and enhancement of the state-of-the-art techonology 
      (Principal Investigator: Toshiya Senda)
  • 2012.10 - 2018.03 Strategic Basic Research Programes・CREST (Principal Investigator)
     "Structural biology of infection and carcinogenesis by Helicobacter Pylori" 
      (Principal Investigator: Toshiya Senda)
  • 2012. - 2016. Platform for Drug Discovery, Informatics, and Structural Life Science (PDIS) (Analysis Core - Protein production section - Representative)
      Establishing the Automated high-throght put crystallization pipleline and users support system 
      (Principal Investigator: Ruichi Kato)
  • 2012.06 -  SACLA-SFX Project (Co-Investigator, KEK-Representative)
      Rapid Structure determination system for Drug-target proteins using the X-ray free electron laser
      (Principal Investigator: Fumiaki Yumoto)
  • 2012.06 -  SACLA-SFX Project (Co-Investigator, KEK-Representative)
      Rapid Structure determination system for Drug-target proteins using the X-ray free electron laser
      (Principal Investigator: Fumiaki Yumoto)
  • 2012.10 - 2015.03 Grant-in-Aid for Scientific Research on Innovative Areas, Scientific Research (B)
      Mechanistic analyses of chromatin structural changes through the structure of TFIID
      (Principal Investigator: Toshiya Senda)
  • 2012.06 - 2017.03 Grants-in-Aids for Scientific research (KAKENHI), Grant-in-Aid for Scientific Research on Innovative Areas
    New aspect of Ubiqutin system: is enormous roles in protein regulation
      (Co-Investigator:Ryuichi Katot)
  • 2011.04 - 2016.03 Grant-in-Aid for Scientific Research on Innovative Areas, Scientific Research (S)
    "A new frontier of structural biology using ultra high speed micro pixeled detector 
      (Co-Investigator: Nobutaka Shimizu & Naohiro Matsugaki)
  • 2010.06 - 2015.03 Grant-in-Aid for Scientific Research on Innovative Areas
      Structural and functional analyses of chromatin assembly factors 
      (Principle Investigator: Toshiya Senda)